Cryptic crossword clue
Materials extremely powerful, leading to disease 6

The most common and most likely answer to this crossword clue is the 6 letter word PLAIDS

P
L
A
I
D
S

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The straight part
We know that "Materials" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case materials = plaids.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PLAIDS mean?

PLAIDS noun
  1. A type of twilled woollen cloth, often with a tartan or chequered pattern.
  2. A length of such material used as a piece of clothing, formerly worn in the Scottish Highlands and other parts of northern Britain and remaining as an item of ceremonial dress worn by members of Scottish pipe bands.
  3. The typical chequered pattern of a plaid; tartan.

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