Cryptic crossword clue
May she look after girl in empty nursery? 5

The most common and most likely answer to this crossword clue is the 5 letter word NANNY

I've seen this crossword clue in The Guardian
N
A
N
N
Y


Buddy explains!

The straight part
We know that "May she look after girl in empty nursery?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case may she look after girl in empty nursery? = nanny.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NANNY mean?

NANNY noun
  1. A child's nurse.
  2. A grandmother.
  3. A godmother.
  4. A female goat.
NANNY verb
  1. To serve as a nanny.
  2. To treat like a nanny's charges; to coddle.

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