Cryptic crossword clue
May take note, having first letters of font underlined with lines in bold style 8

The most common and most likely answer to this crossword clue is the 8 letter word MANFULLY

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MANFULLY mean?

MANFULLY adverb
  1. In a manful manner; with the characteristics considered typical of a man, such as strength, courage, and determination.

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