The most common and most likely answer to this crossword clue is the 10 letter word MISLEADERS
I've seen this crossword clue in The Guardian
M
I
S
L
E
A
D
E
R
S
Buddy explains!
The straight part
We know that "they are not to be trusted" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case they are not to be trusted = misleaders.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.