The most common and most likely answer to this crossword clue is the 8 letter word TITRATED
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TITRATED mean?
TITRATED verb- To ascertain the amount of a constituent in a solution (or other mixture) by measuring the volume of a known concentration (the "standard solution") needed to complete a reaction.
- To adjust the amount of a drug consumed until the desired effects are achieved.