Cryptic crossword clue
Men are set to put a new handle on 6

The most common and most likely answer to this crossword clue is the 6 letter word RENAME

I've seen this crossword clue in The Guardian
R
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Buddy explains!

The straight part
We know that "put a new handle on (6)/put a new handle on" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case put a new handle on (6)/put a new handle on = rename.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RENAME mean?

RENAME noun
  1. An instance of renaming.
RENAME verb
  1. To give a new name to.

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