Cryptic crossword clue
Men in black have trouble with spooks 6

The most common and most likely answer to this crossword clue is the 6 letter word SCARES

I've seen this crossword clue in Financial Times
S
C
A
R
E
S

Buddy explains!

The straight part
We know that "spooks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spooks = scares.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SCARES mean?

SCARES noun
  1. A minor fright.
  2. A cause of slight terror; something that inspires fear or dread.
  3. A device or object used to frighten.

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