Cryptic crossword clue
Mentally affecting Hitchcock film running 12

The most common and most likely answer to this crossword clue is the 12 letter word PSYCHOACTIVE

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Mentally affecting" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mentally affecting = psychoactive.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PSYCHOACTIVE mean?

PSYCHOACTIVE noun
  1. Any drug that affects the mind or mental processes.
PSYCHOACTIVE adjective
  1. (pharmaceutical effect) Affecting the mind or mental processes.

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