Cryptic crossword clue
Mentally ready to have old Englishman immigrant replace university’s late guide 10

The most common and most likely answer to this crossword clue is the 10 letter word PSYCHOPOMP

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Buddy explains!

The straight part
We know that "late guide" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case late guide = psychopomp.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PSYCHOPOMP mean?

PSYCHOPOMP noun
  1. A spirit, deity, person, etc., who guides the souls of the dead to the afterlife.

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