Cryptic crossword clue
Merrier boy requiring WC desperately, in little drinking establishment 12

The most common and most likely answer to this crossword clue is the 12 letter word MICROBREWERY

I've seen this crossword clue in Financial Times
M
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Buddy explains!

The straight part
We know that "little drinking establishment" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case little drinking establishment = microbrewery.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MICROBREWERY mean?

MICROBREWERY noun
  1. A small commercial brewery, often one serving a single pub at which it is physically located; in the United States, often used to indicate a brewery that produces fewer than 15,000 barrels of beer annually.

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