Cryptic crossword clue
Messi having run rings round Man Utd at beginning of each half, popular back provides protection 9

The most common and most likely answer to this crossword clue is the 9 letter word IMMUNISES

I've seen this crossword clue in Financial Times
I
M
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Buddy explains!

The straight part
We know that "provides protection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case provides protection = immunises.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMMUNISES mean?

IMMUNISES verb
  1. To make someone or something immune to something.
  2. To inoculate someone, and thus produce immunity from a disease.

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