Cryptic crossword clue
Middle-distance runner holding a large envelope 6

The most common and most likely answer to this crossword clue is the 6 letter word MAILER

M
A
I
L
E
R

Buddy explains!

The straight part
We know that "large envelope" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case large envelope = mailer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MAILER mean?

MAILER noun
  1. One who sends mail.
  2. A computer program that sends electronic mail.
  3. A packet or container designed for postal use.
  4. A mailshot; advertising sent by mail.

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