The most common and most likely answer to this crossword clue is the 6 letter word MILIEU
I've seen this crossword clue in Financial Times
M
I
L
I
E
U
More clues leading to the result MILIEU
- Note falsehood with universal setting
- The writer’s turned round story associated with university environment
- Mike needs one place setting
- Note fake news for all to see in context
- One needing rest in Greek character’s location
- Note position – classy environment
- Motorway place setting
- Position on course behind road, university setting
- Setting maybe at Watford Gap?
- The setter’s back story prior to university environment
Buddy explains!

The straight part
We know that "setting" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case setting = milieu.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MILIEU mean?
MILIEU noun- Medium.
- Social setting or environment.