The most common and most likely answer to this crossword clue is the 6 letter word MOTHER
M
O
T
H
E
R
More clues leading to the result MOTHER
- Female relative — male different
- One expecting Bottom here in play
- One expecting the right to wear second medal
- Girl in club’s second tango in the dress
- Bloke is gutted after female stops saying she's pregnant
- Male, different relative
- Be overprotective and conceal everything but the face
- 22 I’m not sure is native
- Ornamental material revealed by girl’s mum
- Minute remaining, matron!
Buddy explains!

The straight part
We know that "matron" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case matron = mother.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MOTHER mean?
MOTHER noun- A (human) female who has given birth to a baby
- A human female who parents an adopted or fostered child
- A human female who donates a fertilized egg or donates a body cell which has resulted in a clone.
- A pregnant female, possibly as a shortened form of mother-to-be.
- A female parent of an animal.
- A female ancestor.
- A source or origin.
- Something that is the greatest or most significant of its kind. (See mother of all.)
- (when followed by a surname) A title of respect for one's mother-in-law.
- Any elderly woman, especially within a particular community.
- Any person or entity which performs mothering.
- The principal piece of an astrolabe, into which the others are fixed.
- The female superior or head of a religious house; an abbess, etc.
- Hysterical passion; hysteria; the uterus.
- To give birth to or produce (as its female parent) a child. (Compare father.)
- To treat as a mother would be expected to treat her child; to nurture.
- A stringy, mucilaginous or film- or membrane-like substance (consisting of acetobacters) which develops in fermenting alcoholic liquids (such as wine, or cider), and turns the alcohol into acetic acid with the help of oxygen from the air.
- To cause to contain mother.
- (of an alcohol) To develop mother.
- Motherfucker.
- A striking example.
- A person (especially an entomologist) or animal that catches moths.