Cryptic crossword clue
Mistaking one end of mastoid for the other, accept responsibility for flat bone 8,5

The most common and most likely answer to this crossword clue is the 8 plus 5 letter word SHOULDER BLADE

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Buddy explains!

The straight part
We know that "flat bone" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case flat bone = shoulder blade.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SHOULDER BLADE mean?

SHOULDER BLADE noun
  1. Either of the large flat bones at the back of the shoulder.

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