The most common and most likely answer to this crossword clue is the 4 letter word DEMI
D
E
M
I
More clues leading to the result DEMI
- Mistresses minded home naughtily — no husband in sight
- I am embraced by devilish European that ensnares one shady lady
- Passing entrance of cafe, see such a wine?
- Loose women said to mingle with monied men
- Half sounds like more!
- Passing first of cases of white wine
- Almost relinquish Patrick’s co-star in “Ghost”
Buddy explains!

The straight part
We know that "Mistresses" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mistresses = demi.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DEMI mean?
DEMI noun- A fifty pence piece.
- A bottle of wine containing 0.375 liters of fluid, 1/2 the volume of a standard bottle; a split.
- Demisexual.
- A printing paper size, 17½ inches by 22½ inches.
- One holding a demyship, a kind of scholarship for Magdalen College, Oxford.
- Junior scholar, specifically at Magdalen College, Oxford.