Cryptic crossword clue
Modern aid's worked out what letters of anagram could be 10

The most common and most likely answer to this crossword clue is the 10 letter word RANDOMISED

I've seen this crossword clue in The Times
R
A
N
D
O
M
I
S
E
D

Buddy explains!

The straight part
We know that "what letters of anagram could be" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case what letters of anagram could be = randomised.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RANDOMISED mean?

RANDOMISED verb
  1. To arrange randomly; to make random

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