Cryptic crossword clue
Monastery officer in rare upset about business 10

The most common and most likely answer to this crossword clue is the 10 letter word INFIRMARER

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Buddy explains!

The straight part
We know that "Monastery officer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case monastery officer = infirmarer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFIRMARER mean?

INFIRMARER noun
  1. One who took care of the sick, especially in a medieval monastery or nunnery; physician.

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