The most common and most likely answer to this crossword clue is the 7 letter word ODDS-ON
I've seen this crossword clue in The Guardian
O
D
D
S
-
O
N
More clues leading to the result ODDS-ON
- Exceptional boy, very likely to succeed
- Pretty likely old theologian gets what Christ was to God
- Likely to happen for strange boy
- Strange boy’s most likely to succeed
- Strange boy most likely to win
- More often than not it’s mismatched, my boy!
- Peculiar boy becomes favourite to win
- Likely lad sat on by old theologian
- Unusual boy, very likely to succeed
- Weird boy having better than even chance of winning
Buddy explains!

The straight part
We know that "More often than not" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case more often than not = odds-on.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ODDS-ON mean?
ODDS-ON adjective- Having a chance of winning that is better than even.
- In which the amount won on a bet is less than the amount staked.
- Very likely.