Cryptic crossword clue
More than one muscle in climbing that is supporting an excessive amount 6

The most common and most likely answer to this crossword clue is the 6 letter word GLUTEI

G
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Buddy explains!

The straight part
We know that "More than one muscle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case more than one muscle = glutei.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GLUTEI mean?

GLUTEI noun
  1. One of the several muscles of nates, which arises from a pelvis and inserted into a femur.
  2. Short for gluteus maximus, the large muscles in the human buttocks.

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