Cryptic crossword clue
More than one sure pharmacy’s closing: couple of tablets needed? 5

The most common and most likely answer to this crossword clue is the 5 letter word YESES

I've seen this crossword clue in The Guardian
Y
E
S
E
S

Buddy explains!

The straight part
We know that "More than one sure" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case more than one sure = yeses.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does YESES mean?

YESES noun
  1. An affirmative expression; an answer that shows agreement or acceptance.
  2. A vote of support or in favor/favour of something.
YESES verb
  1. To agree with, affirm, approve.
  2. To attempt to flatter someone by habitually agreeing

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