Cryptic crossword clue
Mortification of the flesh – it may be character-building having endless cross to bear 8

The most common and most likely answer to this crossword clue is the 8 letter word GANGRENE

G
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Buddy explains!

The straight part
We know that "Mortification of the flesh" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mortification of the flesh = gangrene.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GANGRENE mean?

GANGRENE noun
  1. The necrosis or rotting of flesh, usually caused by lack of blood supply.
  2. A damaging or corrupting influence.
GANGRENE verb
  1. To produce gangrene in.
  2. To be affected with gangrene.
  3. To corrupt; To cause to become degenerate.

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