Cryptic crossword clue
Most clamorous one interrupting most prying 8

The most common and most likely answer to this crossword clue is the 8 letter word NOISIEST

I've seen this crossword clue in The Daily Telegraph
N
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Buddy explains!

The straight part
We know that "Most clamorous" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most clamorous = noisiest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NOISIEST mean?

NOISIEST adjective
  1. Making a noise, especially a loud unpleasant sound
  2. Full of noise.
  3. Unpleasant-looking and causing unwanted attention

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