The most common and most likely answer to this crossword clue is the 8 letter word RUSTIEST
I've seen this crossword clue in Independent
R
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More clues leading to the result RUSTIEST
Buddy explains!
The straight part
We know that "Most neglected" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most neglected = rustiest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does RUSTIEST mean?
RUSTIEST adjective- Marked or corroded by rust.
- Of the rust color, reddish or reddish-brown.
- Lacking recent experience, out of practice, especially with respect to a skill or activity.
- Of clothing, especially dark clothing: worn, shabby.
- Affected with the fungal plant disease called rust.