Cryptic crossword clue
Most painful? Then put your feet up 6

The most common and most likely answer to this crossword clue is the 6 letter word SOREST

I've seen this crossword clue in The Guardian
S
O
R
E
S
T


Buddy explains!

The straight part
We know that "Most painful" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most painful = sorest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SOREST mean?

SOREST adjective
  1. Causing pain or discomfort; painfully sensitive.
  2. Sensitive; tender; easily pained, grieved, or vexed; very susceptible of irritation.
  3. Dire; distressing.
  4. Feeling animosity towards someone; annoyed or angered.
  5. Criminal; wrong; evil.

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