The most common and most likely answer to this crossword clue is the 8 letter word WEIRDEST
I've seen this crossword clue in The Times
W
E
I
R
D
E
S
T
More clues leading to the result WEIRDEST
- Most peculiar doctor that is retreating in one direction
- Dire stew cooked up, most odd
- Most unorthodox partnership that is securing runs
- Ride off in direction of sunset? That’s most odd
- Dries out inside, not dry outside? Most odd
- Extremely unusual to stride away after royal address
- The Observer embracing Right, that is most odd
- Most rum we tried is ultimately drunk
Buddy explains!

The straight part
We know that "Most peculiar" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most peculiar = weirdest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does WEIRDEST mean?
WEIRDEST adjective- Having an unusually strange character or behaviour.
- Deviating from the normal; bizarre.
- Of or pertaining to the Fates.
- Connected with fate or destiny; able to influence fate.
- Of or pertaining to witches or witchcraft; supernatural; unearthly; suggestive of witches, witchcraft, or unearthliness; wild; uncanny.
- Having supernatural or preternatural power.