Cryptic crossword clue
Most prudish minister accepts one’s heartless sins 9

The most common and most likely answer to this crossword clue is the 9 letter word PRISSIEST

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Buddy explains!

The straight part
We know that "Most prudish" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most prudish = prissiest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PRISSIEST mean?

PRISSIEST adjective
  1. Excessively prim, proper, particular or fussy.
  2. (usually derogatory) Very feminine or dressy.
  3. Well-mannered, well-behaved.

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