Cryptic crossword clue
Most serene maiden imprisoned in castle wickedly 7

The most common and most likely answer to this crossword clue is the 7 letter word CALMEST

I've seen this crossword clue in The Daily Telegraph
C
A
L
M
E
S
T

Buddy explains!

The straight part
We know that "Most serene" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most serene = calmest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CALMEST mean?

CALMEST verb
  1. To make calm.
  2. To become calm.
CALMEST adjective
  1. (of a person) Peaceful, quiet, especially free from anger and anxiety.
  2. (of a place or situation) Free of noise and disturbance.
  3. (of water) with few or no waves on the surface; not rippled.
  4. Without wind or storm.

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