The most common and most likely answer to this crossword clue is the 6 letter word COYEST
I've seen this crossword clue in The Guardian
C
O
Y
E
S
T
More clues leading to the result COYEST
Buddy explains!
The straight part
We know that "Most shy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most shy = coyest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does COYEST mean?
COYEST adjective- Bashful, shy, retiring.
- Quiet, reserved, modest.
- Reluctant to give details about something sensitive; notably prudish.
- Pretending shyness or modesty, especially in an insincere or flirtatious way.
- Soft, gentle, hesitating.