Cryptic crossword clue
Most successful variety of Silk Cut includes drug 8

The most common and most likely answer to this crossword clue is the 8 letter word LUCKIEST

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Buddy explains!

The straight part
We know that "Most successful" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most successful = luckiest.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LUCKIEST mean?

LUCKIEST adjective
  1. (of people) Favoured by luck; fortunate; having good success or good fortune
  2. Producing, or resulting in, good fortune

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