The most common and most likely answer to this crossword clue is the 8 letter word BLACKEST
I've seen this crossword clue in The Sunday Telegraph
B
L
A
C
K
E
S
T
More clues leading to the result BLACKEST
Buddy explains!

The straight part
We know that "Most tragic" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most tragic = blackest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BLACKEST mean?
BLACKEST adjective- (of an object) Absorbing all light and reflecting none; dark and hueless.
- (of a place, etc) Without light.
- (sometimes capitalized) Of or relating to any of various ethnic groups having dark pigmentation of the skin.
- Designated for use by those ethnic groups which have dark pigmentation of the skin.
- (of a card) Of the spades or clubs suits. Compare red
- Bad; evil; ill-omened.
- Expressing menace, or discontent; threatening; sullen.
- (of objects, markets, etc) Illegitimate, illegal or disgraced.
- Overcrowded.
- (of coffee or tea) Without any cream, milk or creamer.
- Of or relating to the playing pieces of a board game deemed to belong to the "black" set (in chess the set used by the player who moves second) (often regardless of the pieces' actual colour).
- Said of a symbol or character that is solid, filled with color. Compare white.
- Related to the Christian Democratic Union of Germany.
- Clandestine; relating to a political, military, or espionage operation or site, the existence or details of which is withheld from the general public.
- Occult; relating to something (such as mystical or magical knowledge) which is unknown to or kept secret from the general public.
- Protestant, often with the implication of being militantly pro-British or anti-Catholic
- Having one or more features (hair, fur, armour, clothes, bark, etc) that is dark (or black); in taxonomy, especially: dark in comparison to another species with the same base name.
- Foul; dirty.