The most common and most likely answer to this crossword clue is the 7 letter word NAIVEST
I've seen this crossword clue in The Daily Telegraph
N
A
I
V
E
S
T
More clues leading to the result NAIVEST
- Most missing art teacher, at first, after church body’s absorbed one
- . Scotsman rejected underwear that’s most green
- Most open new undergarment clothes top
- Restless natives, far from the most wise?
- Most unsophisticated Scotsman returned undergarment
- Most immature through reversing in retreat
- Most unsophisticated one detached from foolish vanities
- Simplest home — excellent with very small interior
- Extremely simple to move in a waistcoat...
- Most trusting, natives are free
Buddy explains!

The straight part
We know that "Most unsophisticated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most unsophisticated = naivest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.