Cryptic crossword clue
Mostly understand Alchemi taking number in sequence 6

The most common and most likely answer to this crossword clue is the 6 letter word GENOME

G
E
N
O
M
E


Buddy explains!

The straight part
We know that "sequence" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sequence = genome.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GENOME mean?

GENOME noun
  1. The complete genetic information (either DNA or, in some viruses, RNA) of an organism.

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