Cryptic crossword clue
Mother has fifty small offspring that suckle

The most common and most likely answer to this crossword clue is the 7 letter word MAMMALS

I've seen this crossword clue in The Guardian
M
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Buddy explains!

The straight part
We know that "offspring that suckle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case offspring that suckle = mammals.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MAMMALS mean?

MAMMALS noun
  1. An animal of the class Mammalia, characterized by being warm-blooded, having hair and feeding milk to its young.
  2. A vertebrate with three bones in the inner ear and one in the jaw.

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