Cryptic crossword clue
Mule, say, angry about standing in bottom of river 10

The most common and most likely answer to this crossword clue is the 10 letter word CROSSBREED

C
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CROSSBREED mean?

CROSSBREED noun
  1. An organism produced by mating of individuals of different varieties or breeds.
CROSSBREED verb
  1. To produce (an organism) by the mating of individuals of different breeds, varieties, or species; hybridize.
  2. To mate so as to produce a hybrid; interbreed.
  3. To mate (an organism) with another organism so as to produce a hybrid.

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