Cryptic crossword clue
Murder in institution probed by one leading police department 8

The most common and most likely answer to this crossword clue is the 8 letter word HOMICIDE

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "Murder" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case murder = homicide.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HOMICIDE mean?

HOMICIDE noun
  1. The killing of one person by another, whether premeditated or unintentional.
  2. A person who kills another.
  3. (police jargon) A victim of homicide; a person who has been unlawfully killed by someone else.

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