Cryptic crossword clue
Murky ale is off — it may go to someone’s head 8

The most common and most likely answer to this crossword clue is the 8 letter word YARMULKE

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Buddy explains!

The straight part
We know that "it may go to someone’s head" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it may go to someone’s head = yarmulke.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does YARMULKE mean?

YARMULKE noun
  1. A skullcap worn by religious Jewish males (especially during prayer).

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