Cryptic crossword clue
Muse close to Lucian smeared with oil paint 8

The most common and most likely answer to this crossword clue is the 8 letter word EMULSION

I've seen this crossword clue in The Guardian
E
M
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S
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Buddy explains!

The straight part
We know that "paint" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case paint = emulsion.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EMULSION mean?

EMULSION noun
  1. A stable suspension of small droplets of one liquid in another with which it is immiscible.
  2. A colloid in which both phases are liquid.
  3. The coating of photosensitive silver halide grains in a thin gelatine layer on a photographic film.

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