Cryptic crossword clue
Musical instrument is held by thumb, a stringed instrument perhaps 7

The most common and most likely answer to this crossword clue is the 7 letter word SISTRUM

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Buddy explains!

The straight part
We know that "Musical instrument" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case musical instrument = sistrum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SISTRUM mean?

SISTRUM noun
  1. An ancient Egyptian musical instrument, to be shaken, consisting of a metal frame holding percussive metal beads.

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