Cryptic crossword clue
Mutually destructive niece set straight by trainee doctor 11

The most common and most likely answer to this crossword clue is the 11 letter word INTERNECINE

I've seen this crossword clue in The Daily Telegraph
I
N
T
E
R
N
E
C
I
N
E

Buddy explains!

The straight part
We know that "Mutually destructive" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mutually destructive = internecine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTERNECINE mean?

INTERNECINE adjective
  1. Mutually destructive; most often applied to warfare.
  2. Characterized by struggle within a group, usually applied to an ethnic or familial relationship.

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