Cryptic crossword clue
My extra-large infant school originally having tiny pupils 6

The most common and most likely answer to this crossword clue is the 6 letter word MYOSIS

M
Y
O
S
I
S

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MYOSIS mean?

MYOSIS noun
  1. Contraction of the pupil of the eye.

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