Cryptic crossword clue
My nicest port dissolved drug 12

The most common and most likely answer to this crossword clue is the 12 letter word STREPTOMYCIN

I've seen this crossword clue in The Times
S
T
R
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P
T
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M
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N

Buddy explains!

The straight part
We know that "drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drug = streptomycin.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does STREPTOMYCIN mean?

STREPTOMYCIN noun
  1. An aminoglycoside and bactericidal antibiotic administered via intramuscular injection.

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