The most common and most likely answer to this crossword clue is the 3 plus 2 plus 4 letter word NOT AT HOME
I've seen this crossword clue in The Times
N
O
T
A
T
H
O
M
E
More clues leading to the result NOT AT HOME
Buddy explains!

The straight part
We know that "out" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case out = not at home.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.