The most common and most likely answer to this crossword clue is the 6 letter word UNKNOT
U
N
K
N
O
T
More clues leading to the result UNKNOT
- Punk, notwithstanding trousers, to get out of bondage
- Loosen damaged nut securing handle incompletely
- Heading off to bed, never once being loose
- Straighten out trunk, noting contents
- Nameless opponents finally left with team leader to loosen in a way
- Free junk, noticing how strewn it is all inside
- Remove one's tie? Not after well-built guy goes topless
- Kept in trunk, nothing is free
- Remove granny perhaps from drunk notary
Buddy explains!

The straight part
We know that "loosen in a way" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loosen in a way = unknot.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNKNOT mean?
UNKNOT noun- In knot theory, a loop that is not knotted.
- To unfasten (a knot).