Cryptic crossword clue
Narcos’ bust could be the start of great things 6

The most common and most likely answer to this crossword clue is the 6 letter word ACORNS

I've seen this crossword clue in Independent
A
C
O
R
N
S


Buddy explains!

The straight part
We know that "the start of great things" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the start of great things = acorns.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACORNS mean?

ACORNS noun
  1. The fruit of the oak, being an oval nut growing in a woody cup or cupule.
  2. A cone-shaped piece of wood on the point of the spindle above the vane, on the mast-head.
  3. See acorn-shell.
  4. (usually in the plural) A testicle.

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