The most common and most likely answer to this crossword clue is the 6 letter word SPEEDS
I've seen this crossword clue in Independent
S
P
E
E
D
S
Buddy explains!

The straight part
We know that "careers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case careers = speeds.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SPEEDS mean?
SPEEDS noun- The state of moving quickly or the capacity for rapid motion; rapidity.
- The rate of motion or action, specifically / the magnitude of the velocity; the rate distance is traversed in a given time.
- The sensitivity to light of film, plates or sensor.
- The duration of exposure, the time during which a camera shutter is open (shutter speed).
- The largest size of the lens opening at which a lens can be used.
- The ratio of the focal length to the diameter of a photographic objective.
- Amphetamine or any amphetamine-based drug (especially methamphetamine) used as a stimulant, especially illegally.
- Luck, success, prosperity.
- Personal preference.
- A third-order measure of derivative price sensitivity, expressed as the rate of change of gamma with respect to changes in the underlying asset price.
- To succeed; to prosper, be lucky.
- To help someone, to give them fortune; to aid or favour.
- To go fast.
- To exceed the speed limit.
- To increase the rate at which something occurs.
- To be under the influence of stimulant drugs, especially amphetamines.
- To be expedient.
- To hurry to destruction; to put an end to; to ruin.
- To wish success or good fortune to, in any undertaking, especially in setting out upon a journey.
- To cause to make haste; to dispatch with celerity; to drive at full speed; hence, to hasten; to hurry.
- To hasten to a conclusion; to expedite.