Cryptic crossword clue
Nasty bug one got in small busy US city 10

The most common and most likely answer to this crossword clue is the 10 letter word SALMONELLA

I've seen this crossword clue in Financial Times
S
A
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M
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A


Buddy explains!

The straight part
We know that "Nasty bug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nasty bug = salmonella.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SALMONELLA mean?

SALMONELLA noun
  1. Any of several rod-shaped bacteria, of the genus Salmonella, that cause food poisoning and other diseases

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