The most common and most likely answer to this crossword clue is the 11 letter word EXTERMINATE
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Buddy explains!
The straight part
We know that "Nasty extreme tin automaton’s opener" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nasty extreme tin automaton’s opener = exterminate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EXTERMINATE mean?
EXTERMINATE verb- To kill all of (a population of pests or undesirables), usually intentionally.
- To bring a definite end to; finish completely.