Cryptic crossword clue
Nasty headache puts Margaret on edge 6

The most common and most likely answer to this crossword clue is the 6 letter word MEGRIM

M
E
G
R
I
M

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The straight part
We know that "Nasty headache" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nasty headache = megrim.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MEGRIM mean?

MEGRIM noun
  1. A headache; a migraine.
  2. A fancy, a whim, a caprice.
  3. (in the plural) See megrims.
MEGRIM noun
  1. A type of European deep water flatfish, Lepidorhombus whiffiagonis; the whiff or sail-fluke.

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