Cryptic crossword clue
Nasty material’s begun getting seized 5

The most common and most likely answer to this crossword clue is the 5 letter word GUNGE

I've seen this crossword clue in Financial Times
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The straight part
We know that "Nasty material" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nasty material = gunge.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

GUNGE noun
  1. A percussion instrument consisting of a metal disk that emits a sonorous sound when struck with a soft hammer.
  2. A medal or award, particularly Knight Bachelor.
GUNGE noun
  1. An outhouse: an outbuilding used as a lavatory.
  2. The contents of an outhouse pit: shit.
GUNGE noun
  1. A kind of cultivation energy, more powerful than qi.
  2. An advanced practice that cultivates such energy.
GUNGE noun
  1. A soft, sticky or liquid mass; goo; gunk.
  2. Tholin.
GUNGE verb
  1. (often with "up") To clog with gunge.
  2. To cover with gunge.

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