The most common and most likely answer to this crossword clue is the 5 letter word GUNGE
I've seen this crossword clue in Financial Times
G
U
N
G
E
More clues leading to the result GUNGE
- Slime, for example, covering wildebeest’s back
- Piece for example erected, filthy stuff
- Device for spraying glue, extremely sticky stuff
- Nasty material’s begun getting seized
- Good leg exercise? Not beginner’s messy stuff
- Mucky stuff in weapon little good — remove ultimately
- Greek character stuck in mine, rolling around in muck
Buddy explains!

The straight part
We know that "Nasty material" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nasty material = gunge.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
Crossword Answer definitions
GUNGE noun- A percussion instrument consisting of a metal disk that emits a sonorous sound when struck with a soft hammer.
- A medal or award, particularly Knight Bachelor.
- An outhouse: an outbuilding used as a lavatory.
- The contents of an outhouse pit: shit.
- A kind of cultivation energy, more powerful than qi.
- An advanced practice that cultivates such energy.
- A soft, sticky or liquid mass; goo; gunk.
- Tholin.
- (often with "up") To clog with gunge.
- To cover with gunge.